In the era of precision medicine, medical-grade barcode labels are the crucial physical link connecting patients with digital information, and their reliability is directly related to safety. Unlike ordinary labels, the medical environment is full of challenges: chemical disinfectants, high-temperature sterilization, low-temperature storage, and physical abrasion can all cause label failure, leading to serious risks such as misdiagnosis and medication errors. This article provides an in-depth analysis of these unique challenges and explains how to create durable labels that can withstand extreme conditions through a comprehensive solution that combines synthetic materials, specialty adhesives, and chemical-resistant printing technologies. Ensuring that the information on every label is clear, scannable, and durable is the cornerstone of protecting patient safety, improving medical efficiency, and meeting regulatory compliance, and is also an indispensable part of the medical supply chain.